Characterization of the response of bone marrow-derived progenitor cells to cyclic strain: implications for vascular tissue-engineering applications.
作者： Douglas W. Hamilton , Timothy M. Maul , David A. Vorp
DOI: 10.1089/107632704323061726
关键词: Stimulation 、 Strain (chemistry) 、 Bone marrow 、 Vascular tissue engineering 、 Cyclic strain 、 Immunology 、 Biology 、 Cell biology 、 Progenitor cell 、 Cellular differentiation 、 Cytoskeleton
摘要: One of the major failings in vascular tissue engineering is limited capacity autologous differentiated cells to reconstitute tissues. A logical solution use multipotent progenitor cells, which treatments have been underutilized. Although biochemical stimulation has explored differentiate bone marrow-derived (BMPCs) smooth muscle (SMCs), biomechanical forces differentiation remains unexplored. The purpose this work was explore effects cyclic strain alone on BMPC morphology, proliferation, and differentiation. BMPCs were isolated from rat marrow and, after 7 days culture, grew distinct multilayered colonies. stimulated with 10% at 1 Hz for days. Observations showed that inhibited proliferation (p < 0.05) caused alignment F-actin cytoskeleton perpendicular direction strain. In addition, resulted expressio...
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