Development of electrochemical calcium sensors by using silicon nanowires modified with phosphotyrosine.
作者： Xinyan Bi , Wan Ling Wong , Wenjun Ji , Ajay Agarwal , N. Balasubramanian
DOI: 10.1016/J.BIOS.2007.12.012
关键词: Conductance 、 Calcium in biology 、 Electrochemistry 、 Chemistry 、 Calcium 、 Magnesium ion 、 Sodium 、 Potassium 、 Aqueous solution 、 Inorganic chemistry
摘要: This paper reports the electrical detection of calcium ions by using silicon nanowires (SiNWs) as channels in a chemically gated field-effect-transistor (FET) configuration. To obtain selective and sensitive layer for sensing, SiNWs are modified with biologically relevant amino acid phosphotyrosine (p-Tyr), which is able to complex high affinity. It found that when p-Tyr exposed aqueous solutions containing ions, their conductances increase increasing concentration up 10 μM. In contrast, sodium or potassium, they tyrosine (Tyr), no significant conductance observed. finding suggests complexed phosphate group can act positive gate voltage on FET device comprising n-type SiNWs, leads an conductances. The also magnesium ions. However, response times lower than at same concentration. study reported here may pave way designing intracellular sensor permits monitoring real time.
elsevier.com
sci-hub.se 参考文章(28)
Jenny P. Glusker, Structural Aspects of Metal Liganding to Functional Groups in Proteins Advances in Protein Chemistry. ,vol. 42, pp. 1- 76 ,(1991) , 10.1016/S0065-3233(08)60534-3
Daniel C. Harris, Quantitative Chemical Analysis ,(1982)
JB Michael, DB Martin, L Peter, Calcium - a life and death signal Nature. ,vol. 395, pp. 645- 648 ,(1998) , 10.1038/27094
Xin Liu, K. G. Neoh, E. T. Kang, Viologen-Functionalized Conductive Surfaces: Physicochemical and Electrochemical Characteristics, and Stability Langmuir. ,vol. 18, pp. 9041- 9047 ,(2002) , 10.1021/LA026085U
Volker Schmidt, Stephan Senz, Ulrich Gösele, Diameter-dependent growth direction of epitaxial silicon nanowires. Nano Letters. ,vol. 5, pp. 931- 935 ,(2005) , 10.1021/NL050462G
Yi Cui, Qingqiao Wei, Hongkun Park, Charles M Lieber, Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species Science. ,vol. 293, pp. 1289- 1292 ,(2001) , 10.1126/SCIENCE.1062711
Z Li, Bipin Rajendran, TI Kamins, X Li, Y Chen, R Stanley Williams, None, Silicon nanowires for sequence-specific DNA sensing: device fabrication and simulation Applied Physics A. ,vol. 80, pp. 1257- 1263 ,(2005) , 10.1007/S00339-004-3157-1
Zoubida Elbhiri, Yves Chevalier, Jean-Marc Chovelon, Nicole Jaffrezic-Renault, Grafting of phosphonate groups on the silica surface for the elaboration of ion-sensitive field-effect transistors Talanta. ,vol. 52, pp. 495- 507 ,(2000) , 10.1016/S0039-9140(00)00395-7
Justin D Holmes, Keith P Johnston, R Christopher Doty, Brian A Korgel, Control of Thickness and Orientation of Solution-Grown Silicon Nanowires Science. ,vol. 287, pp. 1471- 1473 ,(2000) , 10.1126/SCIENCE.287.5457.1471
S. Ge, K. Jiang, X. Lu, Y. Chen, R. Wang, S. Fan, Orientation‐Controlled Growth of Single‐Crystal Silicon‐Nanowire Arrays Advanced Materials. ,vol. 17, pp. 56- 61 ,(2005) , 10.1002/ADMA.200400474