Weight gain and neuroadaptations elicited by high fat diet depend on fatty acid composition.

摘要: Abstract Overconsumption of food is a major health concern in the western world. Palatable has been shown to alter activity neural circuits, and obesity linked alterations connectivity between hypothalamus cortical regions involved decision-making reward processing, putatively modulating incentive value food. Outlining neurophysiological adaptations induced by dietary intake high fat diets (HFD) thus valuable establish how diet itself may promote overeating. To this end, C57BL/6 mice were fed HFD rich either saturated fatty acids (HFD-S) or polyunsaturated (HFD-P), low-fat control (LFD) for four weeks. Food energy monitored ex vivo electrophysiology was employed assess neuroadaptations lateral (LH) corticostriatal previously associated with intake. In addition, effects on gene expression NMDA, AMPA GABAA receptor subunits investigated. Our data shows that HFD-P had increased daily compared HFD-S LFD. However, increase no obesogenic effects. Electrophysiological recordings demonstrated selective effect glutamatergic neurotransmission LH, which concomitant change mRNA subtypes Gria1, Gria3 Gria4, NMDA subtypes. Furthermore, while synaptic output from subregions not significantly modulated diet, plasticity form long-term depression (LTD) impaired dorsomedial striatum HFD-S. conclusion, study suggests composition only affects weight gain, but also modulate neuronal function brain