Therapies to Increase ApoA-I and HDL-Cholesterol Levels

摘要: Cholesterol is transported around the body in form of lipoprotein (lipid/protein) complexes, because it almost insoluble water. High-density (HDL) particles transport cholesterol from tissues back to liver for excretion. Epidemiological studies have shown an inverse relationship between blood levels HDL-cholesterol (HDL-c) and incidence clinically significant atherosclerosis. The beneficial effects HDL altering atherosclerotic disease are believed involve elevated enhancing efflux arterial walls, increasing arteries This reverse (RCT) pathway used explain both HDL’s role lipid metabolism association HDL-c plasma concentration risk car- diovascular disease. Based on RCT model, ApoA-I attractive target therapeutic intervention. Experimental manipulations increase production been associated with reduced atherogenicity. There a continuing need novel therapies that biosynthesis HDL, inhibit progression even bring about regression Small molecule compounds endogenous would be agents treating dyslipidemias.