Understanding of the immunological heterogeneity of canine mammary carcinomas to provide immunophenotypic features of circulating leukocytes as clinically relevant prognostic biomarkers
作者： J. M. COSTA NETO , A. ESTRELA-LIMA , Márcio Sobreira Silva Araújo , JOÃO MOREIRA DA COSTA-NETO , Lorena Gabriela Rocha Ribeiro
DOI: 10.1007/S10549-011-1452-Z
关键词: Survival analysis 、 Pathology 、 Major histocompatibility complex 、 CD5 、 Canine Mammary Carcinoma 、 Biology 、 Immunophenotyping 、 Animal mortality 、 Mixed tumor 、 CD8 、 Cancer research 、 Oncology
摘要: We have evaluated the phenotypic features of peripheral blood leukocytes as putative novel biomarkers with prognostic values to monitor canine mammary carci- nomas. Female dogs were categorized into distinct groups, referred carcinoma in benign mixed tumor- MC-BMT and carcinoma-MC. Our findings demonstrate that decreased percentage B-cells along increased frequency NK-cells, CD8 ? T-cells, CD5 Low? T-cells beside higher T/B-cells lower CD4 /CD8 ratio hallmarks MC-BMT. Despite expression MHCI MHCII, lymphocytes from MC displayed migration potential suggested by enhanced CD18 events. Although levels macrophage-
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