Interdependence of Cell Growth and Gene Expression: Origins and Consequences

作者: M. Scott , C. W. Gunderson , E. M. Mateescu , Z. Zhang , T. Hwa

DOI: 10.1126/SCIENCE.1192588

关键词: Cell growthComputational biologyCell biologyGene expressionBacterial geneticsProtein expressionExtramuralBiology

摘要: … 2A and the best-fit values of the parameters r max and κ n (table S4), we observed that the parameter κ n exhibited a strong, positive correlation with the growth rate of cells in drug-free …

参考文章(27)
T. Ruusala, D. Andersson, M. Ehrenberg, C.G. Kurland, Hyper-accurate ribosomes inhibit growth. The EMBO Journal. ,vol. 3, pp. 2575- 2580 ,(1984) , 10.1002/J.1460-2075.1984.TB02176.X
Frederick Carl Neidhardt, John L Ingraham, K Brooks Low, Moselio Schaechter, Boris Magasanik, H Edwin Umbarger, Escherichia Coli and Salmonella: Typhimurium Cellular and Molecular Biology ,(1987)
Jeffrey H Miller, Experiments in molecular genetics ,(1972)
Jesper Vind, Michael A. Sørensen, Michael D. Rasmussen, Steen Pedersen, Synthesis of proteins in Escherichia coli is limited by the concentration of free ribosomes. Expression from reporter genes does not always reflect functional mRNA levels. Journal of Molecular Biology. ,vol. 231, pp. 678- 688 ,(1993) , 10.1006/JMBI.1993.1319
Moselio Schaechter, John L. Ingraham, Frederick C. Neidhardt, Physiology of the bacterial cell : a molecular approach Sinauer Associates. ,(1990)
Jes Forchhammer, Lasse Lindahl, Growth rate of polypeptide chains as a function of the cell growth rate in a mutant of Escherichia coli 15 Journal of Molecular Biology. ,vol. 55, pp. 563- 568 ,(1971) , 10.1016/0022-2836(71)90337-8
Roberta Kwok, Five hard truths for synthetic biology Nature. ,vol. 463, pp. 288- 290 ,(2010) , 10.1038/463288A
Arthur L. Koch, Why can't a cell grow infinitely fast? Canadian Journal of Microbiology. ,vol. 34, pp. 421- 426 ,(1988) , 10.1139/M88-074
Nicholas J. Guido, Xiao Wang, David Adalsteinsson, David McMillen, Jeff Hasty, Charles R. Cantor, Timothy C. Elston, J. J. Collins, A bottom-up approach to gene regulation Nature. ,vol. 439, pp. 856- 860 ,(2006) , 10.1038/NATURE04473
Daniel M. Stoebel, Antony M. Dean, Daniel E. Dykhuizen, The Cost of Expression of Escherichia coli lac Operon Proteins Is in the Process, Not in the Products Genetics. ,vol. 178, pp. 1653- 1660 ,(2008) , 10.1534/GENETICS.107.085399