Chlorogenic Acid Interaction with Cisplatin and Oxaliplatin: Studies in Cervical Carcinoma Cells.
作者： Daniela Catanzaro , Raffaella Filippini , Caterina Vianello , Maria Carrara , Eugenio Ragazzi
DOI: 10.1177/1934578X1601100421
关键词: IC50 、 Chlorogenic acid 、 Pharmacology 、 Chemistry 、 Orders of magnitude (mass) 、 In vitro 、 A431 cells 、 Cisplatin 、 Cytotoxicity 、 Oxaliplatin
摘要: The antiproliferative effect of the naturally occurring polyphenol chlorogenic acid (CGA) was evaluated in combination with either cisplatin or oxaliplatin human cervical carcinoma cell lines that were sensitive (A431) resistant to (A431Pt), order provide evidence overcome drug resistance. Cytotoxicity platinating drugs (IC50 - 10(-6) 10(-5) M) enhanced by 1-2 orders magnitude increasing incubation times (1, 4, and 24 hours) two lines. CGA treatment presented low cytotoxicity per se ~ 10(-4) M at h) if compared platinum its activity similar A431Pt cells their A431 counterpart. (10(-6) indicated variable effects on cytotoxicity, ranging from potentiation various degrees antagonism (in cells) no cells). In explain different cytotoxic elicited association CGA, possible presence chemical interactions investigated HPLC analysis. caused evident changes chromatographic profile, suggesting occurrence vitro interactions.
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