Impact of binding to the multidrug resistance regulator protein LmrR on the photo-physics and -chemistry of photosensitizers.

摘要: Light activated photosensitizers generate reactive oxygen species (ROS) that interfere with cellular components and can induce cell death, e.g., in photodynamic therapy (PDT). The effect of especially proteins on the photochemistry photophysics sensitizers is a key aspect drug design correlating response generation specific ROS species. Here, we show complex range effects binding photosensitizer to multidrug resistance protein, produced by bacteria, formers reactivity. We recruitment like molecules LmrR (Lactococcal Regulator) modifies their photophysical properties capacity oxidative stress 1O2 generation, including rose bengal (RB), protoporphyrin IX (PpIX), bodipy, eosin Y (EY), riboflavin (RBF), rhodamine 6G (Rh6G). neutral charged dyes different exited redox potentials, are broadly representative used PDT.