Role of IL-1 Beta in the Development of Human TH17 Cells: Lesson from NLPR3 Mutated Patients
作者： Denise Lasigliè , Elisabetta Traggiai , Silvia Federici , Maria Alessio , Antonella Buoncompagni
DOI: 10.1371/JOURNAL.PONE.0020014
关键词: Interleukin 17 、 Inflammasome 、 Mutation 、 Cytokine 、 Biology 、 Cryopyrin-associated periodic syndrome 、 Autoimmunity 、 Lineage (genetic) 、 Cellular differentiation 、 Immunology
摘要: Background T helper 17 cells (TH-17) represent a lineage of effector T critical in host defence and autoimmunity. In both mouse human IL-1β has been indicated as key cytokine for the commitment to TH-17 cells. Cryopyrin-associated periodic syndromes (CAPS) are group inflammatory diseases associated with mutations NLRP3 gene encoding inflammasome component cryopyrin. this work we asked whether deregulated secretion secondary characterizing these patients could affect IL-23/IL-17 axis.
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