Gene therapy development in hearing research in China

摘要: Sensorineural hearing loss, the most common form of impairment, is mainly attributable to genetic mutations or acquired factors, such as aging, noise exposure, and ototoxic drugs. In field gene therapy, advances in physiological studies profound increases knowledge regarding underlying mechanisms have yielded great progress terms restoring auditory function animal models deafness. Nonetheless, many challenges associated with translation from basic research clinical therapies remain be overcome before a total restoration can expected. recent years, Chinese teams promoted various developmental efforts this field, including sequencing identify additional potential loci that cause deafness, elucidate molecular mechanisms, optimize vectors delivery routes. review, we summarize state focus on therapy model optimization therapeutic strategies China.