Short-term systemic prophylaxis with cefoxitin and doxycycline in colorectal surgery: A prospective, randomized study
作者： Lars Ivarsson , Nils Darle , Jan Gunnar Kewenter , Staffan Seeberg , Ragnar Norrby
DOI: 10.1016/0002-9610(82)90521-9
关键词: Medicine 、 Doxycycline 、 Colorectal surgery 、 Anastomotic leakage 、 Surgery 、 Cefoxitin 、 Prospective randomized study 、 Postoperative infection 、 Antibiotic prophylaxis 、 Inflammatory bowel disease
摘要: Abstract The efficacy of cefoxitin or doxycycline as antibiotic prophylaxis in colorectal surgery was compared 102 elective operations. Both drugs were used perioperatively only. Cefoxitin 55 cases and 47. Ten patients the group 4 had wound infections. Three intraabdominal abscesses seen, one after two prophylaxis. All three due to anastomotic leakage. Bacteriologic studies revealed no negative ecologic effects short-term did protect against serious infectious complications. extended spectrum provided added benefit Patients with inflammatory bowel disease treated preoperatively salicylazosulfapyridine run a greater risk postoperative infection spite
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