Tumours of the Macrophage Series

摘要: The two major categories of true histiocytic malignancies, which are derived from the mononuclear phagocytic system (MPS) lymphoma (THL) and malignant histiocytosis (MH). Although clinicopathologic findings overlap, disorders can be distinguished by their unique expression immunologic markers1. term ‘malignant histiocytosis’ was first used Rappaport to describe a systemic malignancy histiocytes affects entire reticuloendothelial beginning2. A similar disease entity called ‘histiocytic medullary reticulosis’ (HMR) defined Robb-Smith in 19393, but many investigators have regarded terms MH HMR as synonymous4–6. True lymphoma, on other hand, is localized may or not progress disseminated disease7.