GENETICS | Genetic Association Studies in Human Epilepsy and Pharmacogenetics of Antiepilepsy Drugs

摘要: Twenty-first century medicine will be greatly influenced by our growing ability to correlate genotype with phenotype. Genetic association studies offer many promises, but challenges remain before data generated from this approach find clinical application. Decades of research on the human genome, and advances in molecular technology, have culminated an rapidly catalog millions DNA variations any one individual. Comparing form frequency these between persons disease healthy controls holds promise identifying genetic factors that underlie pathology. This information lead direct improvements both diagnostics treatments. In addition, correlation markers response medicinal drugs (pharmacogentics) revolutionize way which are prescribed. Pharmacogenetic add evidence-based help physician determine most appropriate selection a first line drug, dosing titration schedules, possible adverse effects. Improvements phenotyping, statistical interpretation results, consistency methodology across laboratories some major obstacles need addressed for contribute diagnosis treatment complex traits.