Leucine metabolism in patients with Cushing's syndrome before and after successful treatment
作者： S. B. Bowes , J. J. Benn , I. N. Scobie , A. M. Umpleby , C. Lowy
DOI: 10.1111/J.1365-2265.1993.TB02414.X
关键词: Internal medicine 、 Metabolism 、 Cushing syndrome 、 Endocrinology 、 Lean body mass 、 Protein turnover 、 Pathophysiology 、 Weight loss 、 Mole 、 Leucine 、 Biology
摘要: Summary OBJECTIVE Results from studies on the effect of glucocor-ticosteroids protein turnover in both rat and man have been conflicting. The aim this study was to investigate primary cause muscle wasting patients with Cushing's syndrome. DESIGN Studies whole body 1-14C-leucine syndrome before after successful treatment, control subjects. PATIENTS Eleven (n= 5) treatment 11 subjects. MEASUREMENTS Whole determine leucine metabolic clearance rate, production oxidation rate incorporation into protein. RESULTS Plasma concentration (mean ± SEM 100 6 μ mol/l), (9.97 0.11 mol/min/kg), (0.98 mol/min/kg) (0.71 0.09 were all significantly reduced compared subjects (122 mol/l, P < 0.05; 13.61 1.27 mol/min/kg, 1.65 0.12 1.46 0.10 0.001, respectively). Leucine similar subjects. When metabolism expressed terms lean mass (LBM) five subjects, MCR, not different two groups. However, (P< 0.001) (1.07 0.20 mol/min kg LBM) (1.95 mol/min/kg LBM). CONCLUSION We conclude these that associated is primarily due a reduction synthesis.
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