Diagnosis and Management of Adrenocortical Carcinomas

摘要: Adrenocortical carcinomas (ACC) are rare tumors with unfavorable prognosis; they may be functional (hormone secreting) or nonfunctional. The estimated incidence is 1–2 per million population and the overall 5-year survival less than 40 %. Surgery mainstay of treatment in patients localized disease, metastasectomy can performed selected cases. Mitotane a derivative insecticide dichlorodiphenyltrichloroethane has been used adjuvant, locally advanced, metastatic setting ACC. Adjuvant therapy mitotane after surgical excision recommended high-risk In unresectable alone combination chemotherapy. Radiotherapy usually utilized palliative intent; recent retrospective studies also showed benefit postoperative radiotherapy. Targeted therapies tyrosine kinase inhibitors, vascular endothelial growth factor receptor mTOR inhibitors still under investigation.