Synthesis and structure of hypervalent diacetoxybromobenzene and aziridination of olefins with imino-λ3-bromane generated in situ under metal-free conditions.
作者： Md. Mahbubul Hoque , Kazunori Miyamoto , Norihiro Tada , Motoo Shiro , Masahito Ochiai
DOI: 10.1021/OL201868N
关键词: Medicinal chemistry 、 Hypervalent molecule 、 Molecule 、 Yield (chemistry) 、 Intramolecular force 、 Organic chemistry 、 Benzene 、 Catalysis 、 Ligand 、 In situ 、 Chemistry
摘要: Ligand exchange of p-CF3C6H4BrF2 with acetoxy groups using AcOH and Ac2O affords (diacetoxybromo)benzene in a high yield, which undergoes aziridination alkenes the presence TfNH2 sulfamate esters one pot under mild conditions. The proceeds stereospecifically retention stereochemistry olefins at room temperature limiting amounts transition-metal-free one-pot procedure can be applied to intramolecular versions.
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