Lead treatment in vitro at early developmental stage of bone marrow-derived macrophages enhances NO production through IL-1β and IL-6 but not TNF-α
作者： J Song
DOI: 10.1016/S0300-483X(01)00354-7
关键词: In vitro 、 Macrophage 、 Andrology 、 Proinflammatory cytokine 、 Growth factor 、 Precursor cell 、 Interleukin 6 、 Nitric oxide 、 Immunology 、 Biology 、 Bone marrow
摘要: Abstract Lead (Pb2+) is known to decrease or block nitric oxide (NO) production by mature macrophages (mφ). Bone marrow cells were treated with various doses of lead in vitro and the morphological functional changes observed. (1, 10, 20 50 μM) at start culture mφ growth factor (CSF-1), after 6–7 days culture, resultant (bone marrow-derived mφ, BMDM) showed decreased NO production. Unexpectedly, BMDM from lowest does treatment (1.0 increased The was due expression iNOS gene concurrent enhanced transcript levels proinflammatory cytokines such as IL-1β IL-6, but not TNF-α. on a dose-dependent manner. These results suggest that low dose affects developmental characteristics through different cytokines, effects precursor are different.
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