Kinase inhibitor with improved solubility profile
作者： Michael R. Michaelides , Michael L. Curtin , Douglas H. Steinman , James H. Holms
DOI:
关键词: Improved solubility 、 Kinase 、 VEGF receptors 、 Stereochemistry 、 Platelet-derived growth factor receptor 、 Chemistry 、 Aqueous solubility
摘要: 4-Amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide which inhibits protein kinases such as Aurora-kinases and the VEGFR PDGFR families of kinases, with an improved aqueous solubility profile, compositions containing 4-amino-N-[3-(diethylamino)propyl]-3-(4-{[(3-fluorophenyl)carbamoyl]amino}phenyl)thieno[3,2-c]pyridine-7-carboxamide methods treating diseases using are disclosed.
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