Intramolecular electrochemical dehydrogenative N–N bond formation for the synthesis of 1,2,4-triazolo[1,5-a]pyridines
作者： Yong Li , Zenghui Ye , Na Chen , Zhenkun Chen , Fengzhi Zhang
DOI: 10.1039/C9GC01895F
关键词: Intramolecular force 、 Chemistry 、 Combinatorial chemistry 、 Electrochemistry 、 Redox mediator 、 Electrolyte 、 Bond formation
摘要: A metal- and oxidant-free intramolecular dehydrogenative N–N bond formation has been developed under mild scalable electrolytic conditions. Various valuable 1,2,4-triazolo[1,5-a]pyridines were synthesized efficiently from the readily available N-(2-pyridyl)amidines. The reactions conducted in a simple undivided cell constant current conditions with nBu4NBr as both redox mediator electrolyte. This protocol was applied to efficient synthesis of key intermediates for anti-diabetic compounds.
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