Anti-tumor activity of N-thiolated β-lactam antibiotics
作者： Di Chen , Samuel C. Falsetti , Michael Frezza , Vesna Milacic , Aslamuzzaman Kazi
DOI: 10.1016/J.CANLET.2008.03.047
关键词: Breast cancer 、 Cancer research 、 Molecular biology 、 Antibiotics 、 DNA damage 、 Antigen 、 Jurkat cells 、 Cancer 、 In vivo 、 Biology 、 Apoptosis 、 Oncology
摘要: An ongoing strategy for cancer treatment is selective induction of apoptosis in over normal cells. N-thiolated β-lactams were found to induce DNA damage, growth arrest and cultured human However, whether these compounds have a similar effect vivo has not been studied. We report here that with the β-lactam L-1 caused significant inhibition tumor breast xenograft mouse model, associated damage vivo. These results suggest synthetic antibiotic hold great potential be developed as novel anti-cancer drugs.
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