Maintenance azithromycin treatment in pediatric patients with cystic fibrosis: long-term outcomes related to macrolide resistance and pulmonary function.
作者： Gerdien A. Tramper-Stranders , Tom F. W. Wolfs , Andr?? Fleer , Jan L. L. Kimpen , Cornelis K. van der Ent
DOI: 10.1097/01.INF.0000247109.44249.AC
关键词: Pulmonary function testing 、 Lung 、 Respiratory disease 、 Medicine 、 Azithromycin 、 Drug resistance 、 Antibacterial agent 、 Cystic fibrosis 、 Internal medicine 、 Pseudomonas aeruginosa 、 Immunology
摘要: Background:Maintenance azithromycin therapy may improve pulmonary function in patients with cystic fibrosis (CF) Pseudomonas aeruginosa infection because of its antiinflammatory properties. However, might increase macrolide resistance Staphylococcus aureus cultured from
lww.com 
sci-hub.se 参考文章(13)
Masaharu Shinkai, Bruce K. Rubin, Macrolides and airway inflammation in children Paediatric Respiratory Reviews. ,vol. 6, pp. 227- 235 ,(2005) , 10.1016/J.PRRV.2005.06.005
Hong Bin Kim, Bobin Lee, Hee-Chang Jang, Sung Han Kim, Cheol In Kang, Young Joo Choi, Sang Won Park, Bong Su Kim, Eui-Chong Kim, Myoung-Don Oh, Kang Won Choe, A High Frequency of Macrolide-Lincosamide-Streptogramin Resistance Determinants in Staphylococcus aureus Isolated in South Korea Microbial Drug Resistance. ,vol. 10, pp. 248- 254 ,(2004) , 10.1089/MDR.2004.10.248
Christine Rønne Hansen, Tacjana Pressler, Christian Koch, Niels Høiby, Long-term azitromycin treatment of cystic fibrosis patients with chronic Pseudomonas aeruginosa infection; an observational cohort study Journal of Cystic Fibrosis. ,vol. 4, pp. 35- 40 ,(2005) , 10.1016/J.JCF.2004.09.001
Ronald L. Gibson, Jane L. Burns, Bonnie W. Ramsey, Pathophysiology and management of pulmonary infections in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. ,vol. 168, pp. 918- 951 ,(2003) , 10.1164/RCCM.200304-505SO
U. Kastner, J.P. Guggenbichler, Influence of macrolide antibiotics on promotion of resistance in the oral flora of children. Infection. ,vol. 29, pp. 251- 256 ,(2001) , 10.1007/S15010-001-1072-3
Lisa Saiman, Bruce C. Marshall, Nicole Mayer-Hamblett, Jane L. Burns, Alexandra L. Quittner, Debra A. Cibene, Sarah Coquillette, Ann Yunker Fieberg, Frank J. Accurso, Preston W. Campbell III, for the Macrolide Study Group, Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial. JAMA. ,vol. 290, pp. 1749- 1756 ,(2003) , 10.1001/JAMA.290.13.1749
Eric Nuermberger, William R. Bishai, The clinical significance of macrolide-resistant Streptococcus pneumoniae: it's all relative. Clinical Infectious Diseases. ,vol. 38, pp. 99- 103 ,(2004) , 10.1086/380126
Hans F. Berg, Jeroen H. T. Tjhie, Gert-Jan Scheffer, Marcel F. Peeters, Peter H. J. van Keulen, Jan A. J. W. Kluytmans, Ellen E. Stobberingh, Emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of Staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study. Antimicrobial Agents and Chemotherapy. ,vol. 48, pp. 4183- 4188 ,(2004) , 10.1128/AAC.48.11.4183-4188.2004
J Wolter, S Seeney, S Bell, S Bowler, P Masel, J McCormack, Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: A randomised trial Thorax. ,vol. 57, pp. 212- 216 ,(2002) , 10.1136/THORAX.57.3.212
Anne‐Laure Prunier, Brigitte Malbruny, Muriel Laurans, Jacques Brouard, Jean‐François Duhamel, Roland Leclercq, High rate of macrolide resistance in Staphylococcus aureus strains from patients with cystic fibrosis reveals high proportions of hypermutable strains. The Journal of Infectious Diseases. ,vol. 187, pp. 1709- 1716 ,(2003) , 10.1086/374937