From Pavlov to pain: How predictability affects the anticipation and processing of visceral pain in a fear conditioning paradigm.

摘要: Conditioned pain-related fear may contribute to hyperalgesia and central sensitization, but this has not been tested for interoceptive, visceral pain. The underlying ability accurately predict pain is based on predictive cue properties alter the sensory processing cognitive-emotional modulation of thus exacerbating subjective experience. In functional magnetic resonance imaging study using painful rectal distensions as unconditioned stimuli (US), we addressed changes in neural during acquisition subsequently if conditioned (CS) increased responses pain-encoding regions. N=49 healthy volunteers were assigned one two groups underwent 3T fMRI either differential conditioning (predictable) or non-contingent presentation CS US (unpredictable). During a subsequent test phase, signaled randomly by CSs delivered. For acquisition, results confirmed predictable unpredictable group. With regard activation response stimuli, compared group revealed greater (somatosensory cortex, insula) pain-modulatory (prefrontal cingulate cortices, periaqueductal grey, parahippocampus) no evidence sensitization was found, demonstrated enhanced caudate nucleus CS(-)-signaled These findings support that conditioning, affects alters associative learning processes cues signaling pain, does result sensitization.