Tuberculosis and HIV–Needed: A New Paradigm for the Control and Management of Linked Epidemics

摘要: Tuberculosis (TB) and human immunodeficiency virus (HIV) disease have been closely entwined since the early years of HIV/AIDS pandemic. The 2 conditions overlap in their epidemiologic characteristics clinical manifestations are both clothed stigma. They individually carry risk creating social, economic, political instability, which is markedly worsened when they affect a region concert. overwhelming burden due to TB HIV borne by resource-limited countries hardest hit among these sub-Saharan Africa. In Africa, epidemic accelerating what was already massive epidemic, with incidence rate increasing from 146 per 100,000 1990 345 2003. Each contributes morbidity mortality other. now leading cause death persons disease. increases reactivation latent infection (LTBI) progression active more than any other known factor. some countries, percentage patients who coinfected greater 60%. Even appropriate management TB, co-infection increased as consequence HIV-related complications. (Published: 25 September 2007) doi:10.1186/1758-2652-9-3-62 Full text: BioMed Central: http://www.biomedcentral.com/1758-2652/content/9/3/62 PubMed http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758896/