作者: G. DESPOTIS , M. AVIDAN , C. EBY
DOI: 10.1111/J.1538-7836.2009.03412.X
关键词: Hemostasis 、 Patient safety 、 Psychological intervention 、 Cardiac surgery 、 Medicine 、 Recombinant factor VIIa 、 Hemostatic function 、 Point-of-care testing 、 Excessive Bleeding 、 Intensive care medicine
摘要: Excessive bleeding after cardiac surgery can result in increased morbidity and mortality related to transfusion- hypoperfusion-related injuries critical organ systems. Our objective was review mechanisms that as well current emerging interventions reduce transfusion. We discovered of point-of-care (POC) tests hemostatic function facilitate the optimal management excessive transfusion by facilitating administration specific pharmacologic or transfusion-based therapy allowing physicians better differentiate between microvascular surgical bleeding. Emerging like recombinant FVIIa have potential transfusion-related sequelae may be life-saving; however, randomized, controlled trials are needed confirm safety before they used either first-line therapies for prophylaxis. In conclusion, careful investigation role new is essential ability use blood products, decrease operative time and/or re-exploration rates has important implications overall patient health care costs.