Antioxidant effect of Ebselen (PZ 51): peroxidase mimetic activity on phospholipid and cholesterol hydroperoxides vs free radical scavenger activity.
作者： Matilde Maiorino , Antonella Roveri , Fulvio Ursini
DOI: 10.1016/0003-9861(92)90534-4
关键词: Free radical scavenger 、 Antioxidant 、 Hydroperoxyl 、 Phospholipid 、 Radical 、 Biochemistry 、 Chemistry 、 Peroxidase 、 Lipid peroxidation 、 Ebselen
摘要: The selenocompound Ebselen (PZ 51) is a potent inhibitor of lipid peroxidation. This antioxidant effect has been previously attributed both to peroxidase mimetic activity and free radical scavenging capability. In the present paper latter ruled out by competition kinetic analysis based on inhibition carotenoid bleaching hydroperoxyl radicals. Furthermore, evidence reported indicating that exhibits extended cholesterol ester hydroperoxides, besides phospholipid hydroperoxides. According this, we propose unique mechanism capacity reduction hydroperoxides in liposomes or lipoproteins, eventually leading prevention hydroperoxide-dependent
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