Effects of the synthetic enkephalin analogue FK 33-824 in man
作者： BEAT VON GRAFFENRIED , EMILIO DEL POZO , JIRI ROUBICEK , EVA KREBS , WALTER PÖLDINGER
DOI: 10.1038/272729A0
关键词: (+)-Naloxone 、 Analgesic effect 、 Internal medicine 、 Enkephalin 、 Enteral administration 、 Endocrine system 、 Plasma levels 、 High doses 、 Morphine 、 Endocrinology 、 Chemistry 、 Pharmacology
摘要: THE synthetic analogue of methionine enkephalin, FK 33-824, exerts a long-lasting and potent analgesic effect in animals after systemic enteral administration1. In high doses it produces tolerance, cross-tolerance with morphine, dependence monkeys. Like β-endorphin, 33-824 akinaesia rats rabbits. All effects seen can be abolished by naloxone. We report here on the results first studies performed man (tolerance, electroencephalogram (EEG), endocrine profile plasma levels), as basis for future therapeutic studies.
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