Cure of Hepatitis C
作者： Françoise Roudot-Thoraval
DOI: 10.20344/AMP.6148
关键词: Hepatocellular carcinoma 、 Liver disease 、 Disease burden 、 Hepatitis C 、 Pediatrics 、 Cirrhosis 、 Transmission (medicine) 、 Medicine 、 European union 、 Risk factor
摘要: Since the discovery of hepatitis C virus in 1989, many epidemiological data have been acquired, especially Europe. Treatments showed substantial improvement over past 25 years and taken a great leap forward with development direct antiviral agents (DAAs). However, burden remains important Europe more than 5 million individuals living HCV European Union. The peak highest incidence occurred between 1970 1990 most countries through transfusion, unsafe care intravenous drug use. Transmission among intra-venous users is still an issue countries, providing majority new cases infection. Due to chronic state viral infection usual slow progression liver disease, prevalence around 2010, but complications, such as decompensated cirrhosis hepatocellular carcinoma come countries.1 risk usually estimated at 10 20% 20 30 evolution,2 higher men women, this increases case comorbidities excessive alcohol consumption, diabetes, obesity, HBV or HIV coinfection. can be 2 3% per year that 1 4% year, also depending on presence comorbidities. In next future, challenge will identify infected people treat effective treatments all patients developing objective decreasing disease burden. Large discrepancies exist terms knowledge burden, rate screened access treatment. All these factors play major role expected evolution epidemics. where use has factor transmission, screening treatment are low level (e.g. England), cirrhosis, HCC transplant increase coming years. By contrast, transfusions played large diffusion epidemics,
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