Next generation immunotherapy for tree pollen allergies.
作者： Yan Su , Eliezer Romeu-Bonilla , Teri Heiland
DOI: 10.1080/21645515.2017.1367882
关键词: Immunology 、 Medicine 、 Clinical trial 、 Review article 、 Allergy 、 Allergen 、 Immunotherapy 、 Tree pollen 、 Cedar pollen 、 Pollen
摘要: Tree pollen induced allergies are one of the major medical and public health burdens in industrialized world. Allergen-Specific Immunotherapy (AIT) through subcutaneous injection or sublingual delivery is only approved therapy with curative potential to allergies. AIT often associated severe side effects requires long-term treatment. Safer, more effective convenient allergen specific immunotherapies remain an unmet need. In this review article, we discuss current progress applying protein peptide-based approaches DNA vaccines clinical challenges posed by tree lens preclinical animal models trials, emphasis on birch Japanese red cedar
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