Presence of brain pathology in deceased subjects with and without chronic obstructive pulmonary disease

摘要: Patients with chronic obstructive pulmonary disease (COPD) have extrapulmonary co-morbidities, such as cardiovascular disease, musculoskeletal wasting and neuropsychological conditions. To date, it remains unknown whether to what extent COPD is associated a higher prevalence of brain pathology. Therefore, the aim this retrospective study was compare neuropathological changes between deceased donors without COPD. Brain autopsy reports age-matched (n = 89) from Netherlands Bank were assessed for demographics, cause death, co-morbidities The degenerative comparable (50.6% vs. 61.8%, p > 0.05). Neoplastic reported in minority (5.6% 10.1%, After correction cerebrovascular accident or cardiac death Charlson co-morbidity index score, vascular among control versus (27.0% 11.2%, adjusted 0.013, odds ratio 2.98). did not reveal differences presence neoplastic changes. Vascular described more often controls. Prospective studies including spirometry structural functional imaging should corroborate our findings.