Impact of 11C-methionine positron emission tomography/computed tomography on radiation therapy planning and prognosis in patients with primary brain tumors.

摘要: AIMS AND BACKGROUND There is limited evidence regarding the impact of 11C-methionine positron emission tomography/computed tomography (MET-PET/CT) on radiation therapy planning primary brain tumors. Our aim was to assess effect this imaging modality treatment volumes and clinical outcome patients eligible for in oncologic setting. METHODS STUDY DESIGN Between November 2009 May 2012, 31 consecutive (male:female, 20:11; mean age, 53.0 years) with pathologically proven primary/relapsed glioma were treated at Humanitas Research Hospital. All submitted same multi-imaging protocol including MET-PET/CT biological target volume (PET) contrast-enhanced magnetic resonance imaging/CT gross tumor volume, order define volume. Different compared analyzed respect modification after disease outcome. In 19/31 cases, re-evaluated completing radiotherapy, these progression-free survival overall determined. The study data collection approved by local ethics committee. RESULTS completed treatment. 29 patients, a defined (mean 18.3 cc), which 20 cases (65%) resulted (mean, 65.9 cc; range, 8.5-165.6). other two PET negative did not influence planning. percentage added 9.2%, ranging between -29% 38%. With follow-up 5.4 months, according only predictor demonstrating significant correlation both ( P = 0.018) (P 0.003). None factors evaluated analyses, histology, previous treatment, uptake, correlated CONCLUSIONS Despite population, our indicate that can have Moreover, appears be group patients.