ENHANCEMENT OF SKIN GRAFTS IN THE MOUSE. THE COMBINED USE OF SPECIFIC AND NONSPECIFIC IMMUNOSUPPRESSION.

摘要: Enhancement of skin grafts in mice by passively administered alloantiserum was examined conjunction with the simultaneous use other immunosuppressive regimens. It could be clearly shown that when a "weak" antilymphocyte serum (ALS) used, significant further prolongation graft survival occurred over obtained enhancing antiserum alone, and these two separate effects were synergistic. When "strong" ALS no synergistic apparent unless given almost continuously. A similar, but less impressive synergism seen azathioprine used together. Azathioprine, like ALS, presumably acts on T cells, whereas drugs directed against B such as cyclophosphamide prednisolone, failed to show any effect.