Zeb1 promotes androgen independence of prostate cancer via induction of stem cell-like properties.

摘要: Current androgen deprivation therapy often leads to independence. However, mechanism of the therapeutic failure is still not well understood. Here, we demonstrate elevated expression Zeb1 in androgen-independent prostate cancer cells and tumors castrated PTEN conditional knockout mice. While shRNA resulted a sensitization cells, forced caused androgen-dependent be more resistant deprivation. Moreover, such effects appeared mediated by induction pluripotent genes or stem cell-like properties. Collectively, these findings suggest that inhibition might potential strategy for treatment cancer.