Central Composite Design for Optimization of Zoledronic Acid Loaded PLGA Nanoparticles

作者: Ongun Mehmet Saka , Umut Can Öz , Berrin Küçüktürkmen , Burcu Devrim , Asuman Bozkır

DOI: 10.1007/S12247-018-9365-6

关键词: NanoparticleCentral composite designBone regenerationMaterials scienceZeta potentialDifferential scanning calorimetryPLGAChemical engineeringDispersityParticle size

摘要: Zoledronic acid (ZA) is one of the drugs used clinically for treatment osteoporosis, and its therapeutic effect due to inhibition osteoclastic cells leading bone resorption. The aim this study developing an optimization method poly(lactide-co-glycolide) (PLGA) nanoparticles ZA which intended local application enable guided regeneration. Three formulation parameters (ZA content, PLGA/Pluronic F68 ratio, organic aqueous phase ratio) were optimized evaluate their effects on particle size (Y1), polydispersity index (PDI) (Y2), zeta potential (Y3), entrapment efficiency (Y4) utilizing central composite experimental design (CCD). Interaction among components was studied by Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray diffraction analysis. Morphology visualized with transmission electron microscopy (TEM). Stability studies also carried out 6 months. results revealed that significantly affected Y1, Y2, Y3, Y4 nanoparticles. developed quadratic model showed high correlation (R2 > 0.84) between predicted response evaluated parameters. Spherical low mean (  39.54%) obtained nanoparticle maintained colloidal stability use CCD ZA-loaded PLGA has provided accessibility optimum properties less procedure therefore presents important predicting prepared polymer commonly in field drug delivery.

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