An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis

摘要: Abstract There has been little information to date based on the potential health effects and hazards associated with inhalation of carbon nanofibrous materials by workers despite their growing use in industry. This study examines vitro a range nanofibres nanotubes for ability stimulate release pro-inflammatory cytokine TNF-α reactive oxygen species (ROS) from monocytic cells. Also assessed were toxic effect nanomaterials cells phagocytic after exposure. Our studies showed that cellular response varied fibre morphology state aggregation; long, straight, well-dispersed nanofilaments produced significantly more ROS compared highly curved entangled materials. We also demonstrated cell was reduced exposure all used this study. Microscopic examination treatment ‘frustrated phagocytosis’, The frustrated phagocytosis suggests clearance lungs macrophages may be impaired. no evidence at any doses or time points used. These considerations have important consequences exposed these nanomaterials.