Discovery, Biosynthesis, and Heterologous Production of Loonamycin, a Potent Anticancer Indolocarbazole Alkaloid
作者： Cheng Long Yang , Bo Zhang , Wen Wen Xue , Wu Li , Zi Fei Xu
DOI: 10.1021/ACS.ORGLETT.0C01456
关键词: Biosynthesis 、 Heterologous expression 、 Chemistry 、 Alkaloid 、 Indolocarbazole 、 Nocardiopsis flavescens 、 Gene cluster 、 Heterologous 、 Biochemistry 、 Loo
摘要: … the indolocarbazole system from l-tryptophan through tandem oxidations. Briefly, RebO/StaO, a FAD-dependent amino acid oxidase, will convert l-tryptophan or its chlorinated derivative …
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