Long-term dietary supplementation with saury oil attenuates metabolic abnormalities in mice fed a high-fat diet: combined beneficial effect of omega-3 fatty acids and long-chain monounsaturated fatty acids

摘要: Background: Pacific saury is a common dietary component in East Asia. Saury oil contains considerable levels of n-3 unsaturated fatty acids (PUFA) and long-chain monounsaturated (LCMUFA) with aliphatic tails longer than 18 carbons. In our previous study, consumption for 4 to 6 wk improved insulin sensitivity the plasma lipid profile mice. However, long-term effects on metabolic syndrome (MetS) risk factors remain be demonstrated. current we examined mice fed high-fat diet, compared effect PUFA EPA LCMUFA MetS factor diet-induced obese Methods Results: Experiment 1, male C57BL/6 J were either 32 % lard diet (control) or containing 22 plus 10 (saury group) weeks. Although no differences found body weight energy expenditure between control groups, decreased insulin, non–HDL cholesterol, hepatic steatosis, adipocyte size, altered mRNA transcribed from genes involved signaling inflammation adipose tissue. Organ acid analysis revealed that increased (especially n-11 LCMUFA) multiple organs, desaturation index (C16:1/C16:0; C18:1/C18:0) liver 2, (control), 28 4%E PA (EPA group), ad iet 20 %l ard plus12 concentrate (LCMUFA 8 intake organ LCMUFA, respectively. Consumption reduced deposition, de creased hyperinsulinemia, accumulated mainly liver, white tissue, suggesting their possible individual biological improving MetS. Conclusion: Our results suggest oil-mediated improvement may possibly due combined LCMUFA.