Similarity and difference in the characteristics of eosinophilic esophagitis between Western countries and Japan.

摘要: Over the past two decades, incidence and prevalence of eosinophilic esophagitis (EoE) have risen rapidly, especially in Western countries, with cases Japan also showing a gradual increase recent years. However, similarities differences regarding characteristics EoE between countries remain to be clearly elucidated. The current clinical guidelines for diagnosis include symptoms related esophageal dysfunction dense infiltration epithelium. Most affected patients are diagnosed incidentally during medical health check-up asymptomatic typical endoscopic findings suggestive frequently encountered. Clinical Japanese similar those seen populations. predominant symptom is dysphagia, food impaction extremely rare cases. Linear furrows most reported characteristic finding, while an stricture or narrow caliber rarely observed. Treatment strategies drugs, dietary restrictions, dilation when disease advanced formation. Although single therapy using proton-pump inhibitor has been shown achieve symptomatic histological response majority Japan, no prospective randomized control studies that evaluated drug elimination diet presented. Overall, populations, severity seems milder Japan. Additional necessary determine genetic factors, natural history disease, treatment efficacy drugs as compared