作者: Christine L. Melchior , R.D. Myers
DOI: 10.1016/0091-3057(77)90006-5
关键词: Blood alcohol 、 Alcohol 、 Internal medicine 、 Saccharin 、 Tetrahydropapaveroline 、 Fluid intake 、 Medicine 、 Anesthesia 、 Metabolite 、 Endocrinology 、 Cerebral ventricle 、 Alkaloid 、 Toxicology 、 Clinical biochemistry 、 Biochemistry 、 Biological psychiatry 、 Behavioral neuroscience 、 Pharmacology
摘要: Abstract The voluntary preference for ethyl alcohol in Sprague-Dawlet rats was determined over 12 days with water as the alternative fluid. solutions offered to animals were increased systematically concentrations from 3 30%, according a three-bottle, two-choice technique. Tetrahydropapaveroline (THP), tetrahydroisoquinoline derivative, infused repeatedly into lateral cerebral ventricle of each rat through guide tube implanted chronically. metabolite dissolved CSF vehicle, and volume 1.0 μl every 15 min or 4.0 30 around clock, entire 12-day period alcohol-water self-selection. Within 6 start infusion, extraordinary amounts consumed which ranged high 8 17 g per kg day. Both racemic mixture THP S-(-)-THP isomer exerted this alcohol-inducing effect, when they chronically range doses 100 picograms/μl mu;g/μl. Control intraventricular infusions same regimen had no effect on preference. excessive intake during persisted long after cessation infusion regimen, i.e., retests carried out at one, six nine months' intervals. Further, THP-treated simultaneous choice palatable solution saccharin together alcohol, continued drink large volumes alcohol. 24 hr patterns fluid intake, registered continuously by drinkometer, revealed that drinking typically massed within two four bouts night-time interval. During period, blood level reached 0.2%. Withdrawal-like symptoms including wet-dog shakes, elevated tail, whisker twitching occasional convulsive episodes, also observed THP-infused rats. These findings provide support hypothesis an alkaloid metabolite, may be formed both brain periphery, is involved mechanism underlying pathological sustained characteristic disease state alcoholism.