Validation of an HPLC method for the determination of urinary and plasma levels of N1-methylnicotinamide, an endogenous marker of renal cationic transport and plasma flow

作者: Caroline Musfeld , Jérôme Biollaz , Natacha Bélaz , Ulrich W Kesselring , Laurent A Decosterd

DOI: 10.1016/S0731-7085(00)00425-8

关键词: ChemistryRenal blood flowHigh-performance liquid chromatographyUrineInternal standardDerivatizationChromatographyQuantitative analysis (chemistry)KidneyB vitamins

摘要: … We report the optimization and validation of an HPLC method for the measurement of endogenous NMN in biological fluids after derivatization into a fluorescent compound. Plasma is …

参考文章(15)
Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies. Conference report. European Journal of Drug Metabolism and Pharmacokinetics. ,vol. 16, pp. 249- ,(1991) , 10.1007/BF03189968
Jesse W. Huff, William A. Perlzweig, THE FLUORESCENT CONDENSATION PRODUCT OF N1-METHYLNICOTINAMIDE AND ACETONE Journal of Biological Chemistry. ,vol. 167, pp. 157- 167 ,(1947) , 10.1016/S0021-9258(17)35152-9
E GA Carter, Quantitation of urinary niacin metabolites by reversed-phase liquid chromatography. The American Journal of Clinical Nutrition. ,vol. 36, pp. 926- 930 ,(1982) , 10.1093/AJCN/36.5.926
Brian R. Clark, Richard M. Halpern, Roberts A. Smith, A fluorimetric method for quantitation in the picomole range of N1-methylnicotinamide and nicotinamide in serum. Analytical Biochemistry. ,vol. 68, pp. 54- 61 ,(1975) , 10.1016/0003-2697(75)90678-8
Frederic C. Bartter, Catherine S. Delea, Fritz Halberg, A map of blood and urinary changes related to circadian variations in adrenal cortical function in normal subjects. Annals of the New York Academy of Sciences. ,vol. 98, pp. 969- 983 ,(1962) , 10.1111/J.1749-6632.1962.TB30612.X
Mark A. Kutnink, Helio Vannucchi, Howerde E. Sauberlich, A Simple High Performance Liquid Chromatography Procedure for the Determination of N1-Methylnicotinamide in Urine Journal of Liquid Chromatography & Related Technologies. ,vol. 7, pp. 969- 977 ,(1984) , 10.1080/01483918408074019
Katsumi SHIBATA, Blood Pyridine Nucleotide Levels Reflect Niacin Equivalent Intake in Humans Journal of Clinical Biochemistry and Nutrition. ,vol. 3, pp. 37- 45 ,(1987) , 10.3164/JCBN.3.37
L.A Decosterd, A Karagiannis, J.-M Roulet, N Bélaz, M Appenzeller, T Buclin, P Vogel, J Biollaz, High-performance liquid chromatography of the renal blood flow marker p-aminohippuric acid (PAH) and its metabolite N-acetyl PAH improves PAH clearance measurements. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 703, pp. 25- 36 ,(1997) , 10.1016/S0378-4347(97)00396-4