Oxygen indicator dilution curves of the canine cerebral circulation.
作者： P. Grieb , R. E. Forster , P. C. Pape
DOI: 10.1007/978-1-4684-7790-0_10
关键词: TRACER 、 Indocyanine green 、 Dilution curve 、 Cerebral circulation 、 Chemistry 、 Dilution 、 Oxygen 、 Stable isotope ratio 、 Chromatography 、 Isotopes of oxygen
摘要: Indicator-dilution methodology is a useful tool in studies of transcapillary exchange (6,10), but oxygen isotopes have seldom been used such studies, because they require non-standard laboratory techniques. Of the two currently physiological research, positron-emitting oxygen-15 not suitable for indicator-dilution technique, one cannot distinguish between signal originating from unmetabolized 15O2, and that metabolically-formed H2 15O molecules (28). The other stable isotope oxygen-18, which can be detected by mass spectrometric Tb our knowledge, there are only preliminary reports tracer dilution curves. Chinard et al, (8) published 18O2 curve kidney, with 51Crlabelled red blood cells (Cr-rbc) as reference indicator. In experiment, labelled preceeded curve, was attributed to existence diffusional shunt kidney. Forster (13) obtained curves skinned canine hind limb, indocyanine green tracer. these experiments, lagged behind reference.
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