Abstract SY24-01: A SAGA of GCN5 and USP22 in stem cells and cancer

摘要: Histone modifying enzymes are important creating and maintaining epigenetic programs that regulate cell identity growth. Our lab uses genetic approaches to define the full spectrum of functions for these enzymes. For example, we have created a series mutations in mouse Gcn5 (KAT2A) gene order this histone acetyltransferase (AT) mammalian system. is catalytic subunit SAGA ATAC complexes. Deletion led early embryonic death telomere dysfunction. We now defining role maintenance pluripotency ES cells differentiation. data indicate an cofactor both Myc E2F family transcription factors, predicting not only self renewal but also Myc-driven cancers. latest studies deubiquitinase module, revealing new information about composition function during development human diseases. Citation Format: Sharon Y. R. Dent, Boyko Atanassov, Calley Hirsch, Evangelia Koutelou, Zeynep Coban, Xian Jiang Lan, Li Wang. A GCN5 USP22 stem cancer. [abstract]. In: Proceedings 105th Annual Meeting American Association Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Res 2014;74(19 Suppl):Abstract nr SY24-01. doi:10.1158/1538-7445.AM2014-SY24-01