Paper: Modelling estimation and control in the relief of post-operative pain

摘要: The paper arises from collaborative work to explore contributions which the technology of control engineering can make pain relief. One particular demand analgesia system was studied in Fentanyl intravenously infused relieve during first day after total hip-replacement. A mathematical model is presented modelled as difference between discomfort and comfort measured by frequency at patient presses a button. This inherently nonlinear because there no button-pressing when exceeds discomfort. novel estimation scheme handle nonlinearity implemented an on-line microcomputer provide model-based stochastic control. Experimental results trials on 20 real patients 500 simulated validate show that gives substantially better relief than achieved conventional analgesia, robust against modelling errors. Directions for further are indicated it concluded promise basis research mechanisms its