Evolution of Nitric Oxide Synthase Regulatory Genes by DNA Inversion

摘要: DNA inversions are mutations involving major rearrangements of the genome and often regarded as either deleterious or catastrophic to gene function can be associated with genomic disorders, such Hunter syndrome some forms hemophilia. Here, we propose that also an essential hitherto unrecognized component evolution in eukaryotic cells. Specifically, provide evidence ancestral neuronal nitric oxide synthase (nNOS) was duplicated one copy retained its original function, whereas internal inversion occurred other. Crucially, resulted creation new regulatory elements required for termination activation transcription. In consequence, split, two independently expressed genes were created. Through dependence on inversion, this is a fundamentally scheme evolution, which show being particular relevance generation endogenous antisense-containing RNA molecules. Functionally, transcripts operate natural negative regulators expression they related through common ancestor.