Comparison of Dobutamine stress echocardiography and 99m-technetium sestamibi SPECT myocardial perfusion scintigraphy for predicting extent of coronary artery disease in patients with healed myocardial infarction

摘要: This study compares the value of dobutamine stress echocardiography and 99m-technetium methoxyisobutyl-isonitrile (MIBI) single-photon emission computed tomography (SPECT) in assessment extent location coronary narrowing patients with healed myocardial infarction. Dobutamine (up to 40 μg/kg/min)-atropine 1 mg) (DSE) conjunction MIBI SPECT was performed 72 (52 men, mean age 57 ± 11 years) infarction referred for evaluation ischemia. Ischemia defined as new or worsened wall motion abnormalities at DSE reversible perfusion defects SPECT. Significant stenosis (≥50% luminal diameter stenosis) infarct-related artery detected 45 other arteries 22 patients. Sensitivity specificity remote ischemia diagnosis were 68% (95% confidence interval [CI] 80) 93% (CI 86 99) DSE, 64% 52 76), 90% 83 98) SPECT, respectively. The positive predictive peri-infarction 89% 81 97) 82% 73 92) 87% 79 95) agreement between both techniques higher than (84% vs 66%, p = 0.02). It is concluded that undergoing testing, are clinically useful methods stenosis.