Dengue and haemophagocytic lymphohistiocytosis

作者: Muznah Kapdi , Ira Shah

DOI: 10.3109/00365548.2011.652667

关键词: Bone marrow examinationEtoposidemyalgiaLeukopeniaHemophagocytosisDengue feverMedicineHemophagocytic lymphohistiocytosisImmunologyRash

摘要: Dengue is characterized by biphasic fever, myalgia or arthralgia, rash, leukopenia, and lymphadenopathy. It self-limiting, dengue-associated haemophagocytic lymphohistiocytosis has been reported in fewer than 20 children worldwide. We report the case of a 4-y-old boy with dengue who continued to have fever for 30 days, hepatomegaly, thrombocytopenia, leukopenia. Bone marrow examination showed haemophagocytes. The child was treated steroids, instead etoposide oral cyclosporine.

参考文章(12)
Chularatana Mahasandana, Kleebsabai Sanpakit, Gavivann Veerakul, Voravarn S Tanphaichitr, Nongnapa Jirarattanasopa, Secondary hemophagocytic lymphohistiocytosis in children: an analysis of etiology and outcome. Journal of the Medical Association of Thailand Chotmaihet thangphaet. ,(2002)
Chih-Jung Chen, Yhu-Chering Huang, Tang-Her Jaing, Iou-Jih Hung, Chao-Ping Yang, Luan Yin Chang, Tzou-Yien Lin, None, Hemophagocytic syndrome: A review of 18 pediatric cases Journal of Microbiology Immunology and Infection. ,vol. 37, pp. 157- 163 ,(2004)
Deepali Jain, Tejinder Singh, Dengue virus related hemophagocytosis: a rare case report. Hematology. ,vol. 13, pp. 286- 288 ,(2008) , 10.1179/102453308X316095
HOWARD R. BIERMAN, Hematodepressive Virus Diseases of Thailand Annals of Internal Medicine. ,vol. 62, pp. 867- 884 ,(1965) , 10.7326/0003-4819-62-5-867
Po-Liang Lu, Hui-Hwa Hsiao, Jih-Jin Tsai, Tun-Chieh Chen, Tyen-Po Chen, Sheng-Fung Lin, Ming-Chu Feng, None, Dengue Virus-associated Hemophagocytic Syndrome and Dyserythropoiesis: A Case Report Kaohsiung Journal of Medical Sciences. ,vol. 21, pp. 34- 39 ,(2005) , 10.1016/S1607-551X(09)70274-8
Ethel R. Nelson, Howard R. Biebman, Ruchee Chulajata, Hematologic phagocytosis in postmortem bone marrows of dengue hemorrhagic fever. (Hematologic phagocytosis in Thai hemorrhagic fever). The American Journal of the Medical Sciences. ,vol. 252, pp. 68- 74 ,(1966) , 10.1097/00000441-196607000-00010
Ernesto Rueda, Angela Méndez, Gerardo González, Síndrome hemofagocítico asociado con dengue hemorrágico Biomedica. ,vol. 22, pp. 160- 166 ,(2002) , 10.7705/BIOMEDICA.V22I2.1155
K. F. Wong, J. K. C. Chan, J. C. W. Chan, W. W. L. Lim, W. K. Wong, Letter to the editor: Dengue virus infection-associated hemophagocytic syndrome American Journal of Hematology. ,vol. 38, pp. 339- 340 ,(1991) , 10.1002/AJH.2830380420
Sanga Pootrakul, Supa Na-Nakorn, Anong Suingdumrong, Natth Bhamarapravati, Bone-marrow studies in Thai haemorrhagic fever. Bulletin of The World Health Organization. ,vol. 35, pp. 54- 55 ,(1966)
Duraisamy G, Ramanathan M, Haemophagocytosis in dengue haemorrhagic fever: a case report. Annals Academy of Medicine Singapore. ,vol. 20, pp. 803- ,(1991)