Detonation nanodiamond toxicity in human airway epithelial cells is modulated by air oxidation

摘要: Abstract Detonation nanodiamonds (DNDs), a nanomaterial with an increasing range of industrial and biomedical applications, have previously been shown to induce pro-inflammatory response in cultured human airway epithelial cells (HAECs). We now show that surface modifications induced by air oxidation DND (AO-DND), including increase oxygen content, formation carboxylic groups associated the appearance high negative zeta potential decrease unpaired electron are accompanied significant loss bioactivity, as measured levels interleukin-8 mRNA HAEC. These findings relevant identification chemical determinants molecular mechanisms inhalational toxicity carbonaceous nanomaterials.