Tyrosine-Mutant AAV8 Delivery of Human MERTK Provides Long-Term Retinal Preservation in RCS Rats
作者： Wen-Tao Deng , Astra Dinculescu , Qiuhong Li , Sanford L. Boye , Jie Li
DOI: 10.1167/IOVS.11-8831
关键词: Molecular biology 、 Electroretinography 、 C-Mer Tyrosine Kinase 、 MERTK 、 Retina 、 Retinal 、 Cell biology 、 MERTK Gene 、 Retinitis pigmentosa 、 Retinal pigment epithelium 、 Biology
摘要: … time that an AAV8 mutant capsid serotype vector has a substantial therapeutic potential for RPE-specific gene delivery. These results suggest that tyrosine-mutant AAV8 vectors hold …
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