Ciprofloxacin-loaded lipid-core nanocapsules as mucus penetrating drug delivery system intended for the treatment of bacterial infections in cystic fibrosis

摘要: Treatment of bacterial airway infections is essential for cystic fibrosis therapy. However, effectiveness antibacterial treatment limited as bacteria inside the mucus are protected from antibiotics and immune response. To overcome this biological barrier, ciprofloxacin was loaded into lipid-core nanocapsules (LNC) high permeability, sustained release activity. Ciprofloxacin-loaded LNC with a mean size 180nm showed by 50% increased drug permeation through mucus. In growth assays, in had similar minimum inhibitory concentrations free P. aeruginosa S. aureus. Interestingly, formation biofilm-like aggregates, which were observed aureus treated ciprofloxacin, avoided exposure to LNC. With combined advantages over non-encapsulated drug, ciprofloxacin-loaded represent promising delivery system prospect an improved antibiotic therapy fibrosis.