Growth Factors and the Retina: Normal Vascularization and Pathologic Neovascularization

摘要: Growth of blood vessels within the human retina is normally completed at birth, and in other mammalian species that have been studied, including dogs, cats, mice, rats, retinal vascularization stops a few weeks after birth.*1 Studies retinas normal adult mice using [3H]-thymidine autoradiography, shown minimal labeling (0.01–0.1%) vascular cell nuclei.5,6 This indicates cells turn over scarcely all during life. Thus, whenever proliferation occurs retina, it pathologic. The new are observed always structurally functionally abnormal. Although derived from circulation by definition begin their growth retina,7 eventually they grow inwardly, break through inner limiting membrane continue on vitreal surface membrane, or actually vitreous (Fig. 2.1). Unlike vessels, thinned often fenestrated endothelial