Prodrugs of Amines

摘要: The amine group is one of the most frequently found functional groups in today’s armory commercially available drugs. Like many pharmaceuticals, compounds containing an can have physicochemical attributes that present obstacles to their safe and effective delivery desired sites action. Amines are generally considered be amenable derivatization reactions thus provide a “synthetic handle” exploited chemical modifications. As result, numerous prodrugs amines been evaluated effort overcome formulation barriers, which include low aqueous solubility, toxicity vehicle, poor membrane permeability, metabolic instability, lack specificity